✈️ 5 Best Ways to Travel from Santiago to Other Chilean Cities (2025)

an aerial view of a city at night

Chile is a country of staggering contrasts—from the arid Atacama Desert in the north to the icy fjords of Patagonia in the south. And if you’re starting your adventure in Santiago, the bustling capital nestled in the Central Valley, you’re in the perfect spot to launch your explorations. But here’s the million-peso question: What’s the best way to get from Santiago to the rest of Chile’s incredible cities?

We’ve been there—crammed into buses, soaring above the Andes, and cruising scenic highways behind the wheel. In this guide, we break down the five best travel methods from Santiago, weighing speed, comfort, cost, and adventure. Curious about which mode suits your itinerary best? Wondering how to balance budget with convenience? Or maybe you want insider tips on hidden gems accessible only by car? Stick with us, and by the end, you’ll be ready to hit the road (or sky) like a seasoned Chilean traveler.

Did you know Chile’s bus network is one of the most extensive and comfortable in South America? Or that flying from Santiago to Patagonia is often cheaper and faster than you might expect? We’ll unpack all this and more, so you can travel smart and savor every moment.

Key Takeaways

  • Flying is fastest for long distances like Atacama and Patagonia, with LATAM, Sky Airline, and JetSMART as top carriers.
  • Buses offer comfort and economy for medium distances, with options ranging from standard to luxury “cama” seats.
  • Renting a car unlocks freedom to explore off-the-beaten-path destinations and wine valleys at your own pace.
  • Train travel is a charming alternative for scenic routes south of Santiago, though limited in scope.
  • Ferries and waterways are essential for southern Patagonia but require combining with land travel from Santiago.

Ready to choose your perfect travel mode? Let’s dive in!

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⚡️ Quick Tips and Facts for Traveling from Santiago to Other Chilean Cities

So, you’ve landed in Santiago and are ready to conquer the long, beautiful beast that is Chile? ¡Fantástico! But you’re probably wondering, “What’s the best way to get from A to B in a country that’s over 4,200 kilometers long?” Don’t you worry, we’ve got you covered. Before we dive deep, here’s a cheat sheet to get you started. And if you want an even broader overview, check out our guide on how to get around Chile during your vacation.

Here’s a quick comparison of your main options for leaving the capital city behind:

Travel Mode Best For Speed 🚀 Cost 💰 Comfort 🛋️ Our Take
✈️ Flying Long distances (e.g., Atacama, Patagonia) Fastest $$$ High The only sane way to travel the full length of Chile unless you have unlimited time.
🚌 Bus Medium distances, budget travel Slow $ Varies (from basic to luxurious!) The classic Chilean experience! Surprisingly comfy and a great way to see the landscape.
🚗 Rental Car Flexibility, scenic routes (e.g., Lake District) Medium $$-$$$ High Unbeatable freedom for the adventurous soul. Perfect for our Adventure Travel lovers!
🚆 Train Short to medium southern routes Medium $$ High A small but scenic and comfortable network. A charming, old-school alternative.

Key Facts at a Glance:

  • ✅ Bus is King: For most inter-city travel, especially for journeys under six hours, buses are the most common and economical choice.
  • ✅ Fly for Extremes: To reach the far north (like Calama for San Pedro de Atacama) or the deep south (Punta Arenas for Patagonia), flying is your best bet.
  • ❌ Safety First: While generally safe, be aware of your surroundings. Petty crime is common in transportation hubs, and the Canadian government warns travelers on intercity buses to be vigilant, especially on overnight routes, as robberies can occur while passengers are sleeping.
  • ✅ Book in Advance: For the best fares on flights and to secure a good seat on popular bus routes (especially during holidays), booking ahead is a must.

🚀 The Evolution of Travel Routes: How Santiago Became Chile’s Transportation Hub

Ever wondered why all roads (and flight paths!) seem to lead to Santiago? It’s no accident! Nestled in the country’s central valley, Santiago’s geographic location made it the natural heart of Chile from colonial times. As the nation grew, so did its infrastructure, with Santiago as the epicenter.

Initially, rugged horse trails and, later, nascent railways connected the capital to the port city of Valparaíso and the fertile southern lands. But the 20th century brought the Pan-American Highway, a game-changer that solidified Santiago’s role as the nexus for ground transportation. Then came the jet age, and Arturo Merino Benítez Airport (SCL) became the primary gateway to Chile and the main hub for domestic flights, connecting the central region to the driest desert in the north and the glacial fields of the south. This historical development is why today, your grand Chilean adventure, whether to explore destinations near or far, almost always begins in Santiago.

✈️ 1. Flying from Santiago: Best Airports and Airlines for Domestic Travel

When time is of the essence, flying is the undisputed champion. Chile’s immense length makes air travel a necessity, not a luxury, for many itineraries. As one travel guide puts it, “Air travel is always the safest way to travel around Chile.”

Santiago’s Gateway: Arturo Merino Benítez Airport (SCL)

All domestic flights depart from Santiago’s main hub, Arturo Merino Benítez International Airport (SCL). It’s a modern, bustling airport located about 30-45 minutes from the city center.

Insider Tip: Be cautious with taxis at the airport. The Government of Canada advises travelers to book and prepay for taxis at an official stand inside the terminal to avoid scams. We’ve had great experiences with pre-booked services like Transvip.

Chile’s Domestic Airlines: The Big Three

You’ve got three main players in the Chilean skies. Choosing between them often comes down to a classic trade-off between cost, comfort, and service.

Airline Vibe Best For What to Expect

LATAM Airlines		 The Flagship Carrier Reliability, extensive network The largest and most established airline. Generally reliable with good service, but often the priciest.

Sky Airline		 The Smart Competitor Balance of cost and service A strong budget competitor. One source notes it’s “not so bad,” which in our experience is fair. It’s a solid no-frills option.

JetSMART		 The Ultra-Low-Cost Rock-bottom fares The new kid on the block. Fares can be incredibly cheap, but beware of extra fees for everything from seat selection to carry-on bags. One blogger shared a negative experience, so manage your expectations.

Our Take: For crucial long-haul domestic flights to Patagonia or Easter Island, we lean towards LATAM for peace of mind. For shorter hops, like Santiago to La Serena, Sky Airline is our go-to for a good balance. We use JetSMART when the price is too good to ignore and we’re traveling light.

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🚌 2. Bus Travel: Exploring Chile’s Extensive Bus Network from Santiago

Ah, the bus. For many of us at Chile Vacay™, this is where our love for Chilean travel began. It’s the most common way to get around, and it’s an incredible way to witness the country’s dramatic landscapes unfold. It’s the heart of Budget Travel in Chile.

Understanding the “Cama” System

Forget cramped buses back home. Chile’s long-distance buses are built for comfort. Here’s the breakdown:

  • Clásico/Pullman: Your standard reclining seat. Fine for short trips.
  • Semi-Cama: More legroom and a deeper recline (around 140 degrees). The most common and a great value.
  • Cama: The king of comfort! These seats recline to about 160 degrees, making them almost flat. Perfect for overnight journeys.
  • Salón Cama / Premium: Pure luxury. Fully flat (180-degree) beds, more privacy, and often better service.

Major Bus Companies & Terminals

From Santiago, buses depart from several terminals, primarily Terminal Alameda and Terminal Sur (they’re right next to each other).

  • Turbus: One of the biggest and most reputable companies, with a massive network.
  • Pullman Bus: Another giant with extensive routes and various service levels.
  • Cruz del Sur: Excellent service, especially for routes heading south to Puerto Montt and Chiloé.

A Word of Caution: While bus travel is fantastic, you need to be smart. The area around Santiago’s Estación Central bus terminal can be sketchy, so be extra vigilant with your belongings. As mentioned, theft can occur on buses, so “always carry your valuables and identification with you and avoid storing them in overhead compartments.” We recommend keeping your passport, phone, and wallet in a small bag you can cuddle with while you sleep.

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  • Recorrido.cl is a fantastic comparison site for booking tickets from multiple companies online.

🚗 3. Renting a Car: Road Trips and Scenic Drives Out of Santiago

Ready to grab the wheel and forge your own path? Renting a car offers unparalleled freedom to explore Chile’s hidden corners, from coastal fishing villages to Andean vineyards. This is the ultimate way to experience Chile’s incredible destinations at your own pace.

The Pros and Cons

✅ Pros ❌ Cons
Ultimate Flexibility: Stop wherever, whenever. Cost: Can be more expensive than buses.
Access Remote Areas: Get off the beaten path. Driving Culture: Chilean drivers can be… assertive. Drive defensively!
Comfort & Convenience: Your own private space. Road Conditions: Main highways are excellent, but rural roads can be unpaved and challenging.

Tips for Renting and Driving in Chile

  • Book Ahead: Especially for automatic cars or during peak season.
  • Get the TAG: Most rental cars come with a “TAG” electronic toll pass for Santiago’s highways. Confirm this with your rental company.
  • Insurance is Key: Your credit card insurance might not be enough. We recommend getting the full coverage offered by the rental agency for peace of mind.
  • SUV for Adventure: If you’re heading to the Andes or Patagonia, consider a 4×4 or at least a vehicle with higher clearance. As one traveler wisely noted, “If you have the money to spend on a larger vehicle, do it! A big SUV is generally safer in an accident than a compact car.”

Major international companies like Avis, Hertz, and Europcar have a strong presence at Santiago’s airport and throughout the city.

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🚆 4. Train Travel Options: The Scenic and Historical Railways from Santiago

While not as extensive as the bus network, Chile’s train system, operated by EFE (Empresa de los Ferrocarriles del Estado), offers a comfortable and wonderfully scenic way to travel south from Santiago. It’s a nostalgic journey and a fantastic Cultural Experience.

The main long-distance service from Santiago’s Estación Central runs south to Chillán, with stops in cities like Rancagua and Talca. The trains are modern and comfortable, offering a relaxing alternative to the highway. It’s not the fastest option, but it’s arguably the most charming, letting you soak in the views of the central valley’s vineyards and farmland.

While the network is currently limited, EFE is investing in expansion, so watch this space! For now, it’s a fantastic option for a relaxed trip into the heart of Chile’s wine country.

🛳️ 5. Alternative Routes: Ferries and Waterways Connecting Chilean Cities

Okay, so you can’t take a ferry directly from Santiago (it’s landlocked, after all!), but understanding the ferry network is crucial for planning onward travel, especially to the south. Once you travel from Santiago to cities like Puerto Montt (by bus or plane), a whole new world of travel opens up via waterways.

Companies like Navimag and Australis operate spectacular ferry routes through the Patagonian fjords, connecting Puerto Montt to Puerto Natales and even further south. These are more than just transport; they are multi-day cruises and a core part of any Adventure Travel itinerary in Patagonia. It’s a slow, breathtakingly beautiful way to see a part of Chile that’s inaccessible by road.

💡 Insider Tips: How to Choose the Best Travel Mode Based on Your Destination and Budget

Feeling overwhelmed by the options? Let’s break it down. The “best” way to travel really depends on where you’re going and what your priorities are.

  • Heading to the Atacama Desert (North):

    • Our Pick: ✈️ Fly. It’s a 2-hour flight to Calama (CJC) versus a 20+ hour bus ride. No contest. From Calama, you can take a shuttle or bus to San Pedro de Atacama.

  • Exploring Valparaíso & Viña del Mar (Coast):

    • Our Pick: 🚌 Bus. It’s cheap, fast (under 2 hours), and buses leave every few minutes from the Pajaritos or Alameda terminals. A car is a hassle with Valparaíso’s steep, narrow streets.

  • Touring the Wine Valleys (Central):

    • Our Pick: 🚗 Rental Car. This is where a car shines. You’ll have the freedom to hop between vineyards in the Maipo, Casablanca, and Colchagua valleys on your own schedule. A true Food & Drink adventure!

  • Journeying to the Lake District (e.g., Pucón, Puerto Varas):

    • Our Pick: 🚌 Overnight Bus (Cama seat). It’s a 9-12 hour journey, perfect for sleeping through. You’ll save on a night’s accommodation and wake up refreshed and ready to explore. Flying to Temuco (ZCO) or Puerto Montt (PMC) is also a great, faster option if you’re short on time.

  • Venturing into Patagonia (South):

    • Our Pick: ✈️ Fly. Fly from Santiago to Punta Arenas (PUQ) or Puerto Natales (PNT). From there, you can rent a car or use buses to explore Torres del Paine National Park.

🌎 Sustainable Travel: Eco-Friendly Ways to Explore Chile from Santiago

We love Chile’s pristine landscapes, and we know you do too. Traveling responsibly is a big part of keeping them beautiful.

  • Choose the Bus: For medium distances, long-distance buses have a significantly lower carbon footprint per passenger than flying.
  • Fly Direct: If you must fly, choose non-stop flights, as takeoffs and landings consume the most fuel.
  • Pack Light: The heavier the plane or bus, the more fuel it burns. Every little bit helps!
  • Carbon Offsets: Consider purchasing carbon offsets for your flights. Many airlines, including LATAM, offer programs to help mitigate your environmental impact.

📅 Seasonal Travel Advice: When to Visit and How Weather Affects Your Journey

Chile’s climate is as varied as its landscape, and the season will definitely impact your travel plans.

  • Summer (December – February): Peak season! Book everything—flights, buses, cars—well in advance. This is the best time for Patagonia, but also the most crowded and expensive. Wildfires can be a risk in central and southern Chile.
  • Fall (March – May): A gorgeous time to travel. Fewer crowds, pleasant weather, and stunning autumn colors in the wine valleys and southern forests.
  • Winter (June – August): The Andes are covered in snow, perfect for skiing. However, be aware that land border passes with Argentina often close due to snow. In the south, expect rain and colder temperatures. Santiago experiences its worst air pollution during these months.
  • Spring (September – November): Another shoulder season gem. Wildflowers bloom in the desert after rare rains (the desierto florido), and Patagonia begins to awaken.

🧳 Packing and Preparation: What to Bring for Different Travel Modes and Destinations

What you pack can make or break your journey. Here are some mode-specific essentials:

  • For Overnight Bus Trips:

    • 🎧 Noise-canceling headphones or earplugs
    • 😴 An eye mask
    • 🧣 A travel blanket or scarf (it can get cold!)
    • 💧 A water bottle and snacks
    • 🔒 A small lock for your daypack

  • For Flights:

    • 📄 Digital and physical copies of your passport and tourist card.
    • 🔋 A portable power bank.
    • ⚖️ A travel scale to avoid overweight baggage fees, especially on budget airlines.

  • For Road Trips:

    • 📱 A phone mount for your car.
    • 🎵 A downloaded playlist or podcast (cell service can be spotty).
    • 💳 Cash for tolls on smaller roads that don’t use the TAG system.
    • 🚗 A valid driver’s license. An International Driving Permit is recommended but not always required.

🔍 Safety and Comfort: Navigating Chile’s Transportation with Confidence

Chile is one of the safest countries in South America, but it’s not immune to problems, especially in big cities. The key is to be a smart, aware traveler.

  • In Bus Terminals and on Buses:

    • Be Vigilant: As the Canadian government warns, petty crime is common in bus stations. Keep your bags in sight and zipped up at all times.
    • Secure Your Valuables: On the bus, especially overnight, keep your passport, phone, and money on your person. Don’t put them in the overhead bin.
    • Choose Reputable Companies: Stick with major bus lines like Turbus or Cruz del Sur, which generally have better safety records.

  • Taxis and Ride-Sharing:

    • The Great Debate: One blogger makes the “hot take” that pre-booked taxis are safer than Ubers. We agree that hailing a random taxi on the street is a bad idea.
    • Our Recommendation: Use ride-sharing apps like Uber or Cabify, or have your hotel call a trusted “radiotaxi” service. At the airport, only use the official taxi counters inside.

  • Driving:

    • Lock Your Doors: Carjackings and “smash-and-grab” thefts can occur. Keep doors locked and valuables out of sight when driving in cities.
    • Beware of Scams: A common trick involves thieves puncturing a tire and then robbing you when you pull over to inspect it. If you get a flat tire in a city, drive slowly to a well-lit, populated area like a gas station before stopping.

While we can’t give exact prices as they fluctuate wildly, here’s a general idea of what to expect for a one-way trip from Santiago.

Destination ✈️ Flight 🚌 Bus (Semi-Cama) 🚗 Rental Car (1 day + fuel)
Valparaíso N/A $ $$
La Serena $$ $$ $$$
San Pedro de Atacama $$$ $$$ (very long!) N/A
Pucón $$$ (to Temuco) $$ $$$$
Puerto Varas $$$ (to Pto. Montt) $$ $$$$
Punta Arenas $$$$ N/A N/A

Pro Tip: For buses and flights, the further in advance you book, the cheaper the fare. For rental cars, sometimes last-minute deals can be found, but it’s risky in high season.

🌟 Hidden Gems: Lesser-Known Cities Easily Accessible from Santiago

Want to escape the crowds? Santiago is the perfect launchpad for some incredible, off-the-beaten-path adventures.

  • Valle del Elqui:

    • Why Go: A mystical valley famous for its clear skies (perfect for stargazing!), pisco distilleries, and bohemian vibe.
    • How to Get There: Take a bus or fly to La Serena, then hop on a local bus for the scenic 1.5-hour ride into the valley to towns like Vicuña or Pisco Elqui.

  • Santa Cruz:

    • Why Go: The heart of the Colchagua Valley, Chile’s premier wine region for red wines. It’s a charming town surrounded by world-class wineries.
    • How to Get There: A rental car is the best option to explore the wineries freely. Alternatively, you can take a 2.5-hour bus ride from Santiago.

  • Radal Siete Tazas National Park:

    • Why Go: A stunning national park featuring a series of seven cascading waterfalls and turquoise pools carved into black basalt rock.
    • How to Get There: This is rental car territory. It’s about a 3.5-hour drive south of Santiago. Public transport is tricky and limited.

📲 Must-Have Apps and Websites for Booking and Navigating Chilean Travel

Navigating Chile is easier than ever with these digital tools at your fingertips.

  • For Booking Flights & Buses:

    • Google Flights: Great for comparing prices across all airlines.
    • Skyscanner: Another excellent flight comparison tool.
    • Recorrido.cl: The absolute best site for comparing and booking bus tickets from nearly all Chilean companies.

  • For Getting Around:

    • Waze / Google Maps: Essential for driving. Waze is particularly good for real-time traffic and police alerts.
    • Uber / Cabify: Your go-to for ride-sharing in major cities.

  • For Accommodation:

    • Booking.com: A huge selection of hotels and hostels.
    • Hostelworld: The best resource for finding and booking hostels.

📚 Conclusion: Your Ultimate Guide to Traveling from Santiago to Chile’s Best Cities

Phew! That was quite the journey through Chile’s transportation options, wasn’t it? From the sky-high convenience of flying with LATAM or Sky Airline, to the scenic and budget-friendly bus rides with Turbus and Pullman Bus, and the freedom of renting your own car to explore hidden gems like Valle del Elqui or Radal Siete Tazas — Santiago truly is the gateway to every Chilean adventure imaginable.

Here’s the bottom line: there’s no one-size-fits-all answer to the best way to travel from Santiago to other cities. Your choice depends on your destination, budget, time constraints, and appetite for adventure. Flying is unbeatable for long distances and time-saving, buses offer a classic Chilean experience with great comfort for medium distances, and renting a car unlocks the freedom to explore at your own pace.

Safety-wise, Chile is generally a safe country, but vigilance is key, especially in bus terminals and urban areas. Pre-book taxis or use ride-sharing apps, keep your valuables close, and drive defensively if you take the wheel.

Remember the unresolved question we teased at the start: What’s the best way to travel in Chile? Now you know — it’s all about mixing and matching modes to suit your itinerary. Whether you’re chasing the northern desert sun, the southern glaciers, or the cultural buzz of coastal cities, Santiago’s transport options have you covered.

Ready to hit the road (or sky)? Pack your bags, book your tickets, and let Chile’s diverse landscapes and vibrant cities enchant you!

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Recommended Reading:

  • Lonely Planet Chile & Easter Island – Amazon
  • Moon Chile by Kelly Bingham – Amazon
  • National Geographic Traveler: Chile – Amazon

❓ Frequently Asked Questions About Traveling from Santiago

What are the most affordable transportation options from Santiago to other Chilean cities?

The most affordable way to travel between Santiago and other Chilean cities is by long-distance bus. Companies like Turbus and Pullman Bus offer a range of seating options, including budget-friendly “clásico” seats and more comfortable “semi-cama” seats. Buses are frequent, reliable, and provide a great way to see the countryside. Booking tickets in advance through platforms like Recorrido.cl can help you snag the best prices.

Is it better to travel by bus or plane when exploring Chile from Santiago?

It depends on your destination and priorities:

  • For long distances (e.g., Santiago to Calama for Atacama Desert, or Santiago to Punta Arenas for Patagonia), flying is the fastest and most practical option. Flights take a few hours compared to 20+ hours by bus.
  • For medium distances (e.g., Santiago to Valparaíso or La Serena), buses offer a more economical and scenic option.
  • If you have time and want comfort, premium “cama” bus seats provide a restful overnight journey.
  • If time is limited, flying is better despite being more expensive.
  • Santiago to Valparaíso: Approximately 1.5 to 2 hours by bus or car. Frequent buses depart from Santiago’s Terminal Alameda.
  • Santiago to Puerto Varas: Around 12 hours by bus (overnight “cama” buses are common) or about 1.5 hours flying to Puerto Montt airport, followed by a short drive.

What are the safety tips for traveling between cities in Chile from Santiago?

  • Keep valuables close: Especially in bus terminals and on buses, avoid storing passports, phones, and wallets in overhead compartments.
  • Use reputable companies: Stick with well-known bus lines like Turbus or Cruz del Sur.
  • Pre-book taxis or use ride-sharing apps: Avoid hailing taxis on the street, particularly at night.
  • Be cautious when driving: Lock doors, avoid stopping in isolated areas, and be aware of scams like punctured tires.
  • Stay informed: Monitor local news for civil unrest or strikes that may affect transport.

How reliable and comfortable are Chile’s long-distance buses?

Chile’s long-distance buses are generally very reliable and comfortable, especially the “semi-cama” and “cama” classes, which offer reclining seats and sometimes amenities like blankets and snacks. Major companies maintain high standards, and buses are often equipped with Wi-Fi and bathrooms. However, punctuality can vary, so always allow buffer time for connections.

Can I rent a car in Santiago and drive to remote areas safely?

Yes, renting a car is a fantastic way to explore Chile’s diverse regions at your own pace. Main highways are well-maintained, but rural and mountainous roads can be challenging and sometimes unpaved. Defensive driving is essential. Consider renting a 4×4 if you plan to visit the Andes or Patagonia. Always check with your rental company about insurance coverage and road restrictions.

And there you have it! Your comprehensive, expert-backed guide to traveling from Santiago to other cities in Chile. Ready to explore? ¡Vamos!

Jacob
Jacob
Articles: 94

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